Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis

Sidhant Chopra; Ashlea Segal; Stuart Oldham; Alexander Holmes; Kristina Sabaroedin; Edwina R Orchard; Shona M Francey; Brian O'Donoghue; Vanessa Cropley; Barnaby Nelson; Jessica Graham; Lara Baldwin; Jeggan Tiego; Hok Pan Yuen; Kelly Allott; Mario Alvarez-Jimenez; Susy Harrigan; Ben D Fulcher; Kevin Aquino; Christos Pantelis; Stephen J Wood; Mark Bellgrove; Patrick D McGorry; Alex Fornito

Journal article

Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis

Sidhant Chopra, Ashlea Segal, Stuart Oldham, Alexander Holmes, Kristina Sabaroedin, Edwina R Orchard, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Jeggan Tiego, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Ben D Fulcher, Kevin Aquino, Christos Pantelis Show all

JAMA Psychiatry | American Medical Association | Published : 2023

DOI: 10.1001/jamapsychiatry.2023.3293

Abstract

Importance: Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown. Objective: To test the hypothesis that brain network architecture constrains cross-sectional and longitudinal gray matter alterations across different stages of psychotic illness and to identify whether certain brain regions act as putative epicenters from which volume loss spreads. Design, Settings, and Participants: This case-control study included 534 individuals from 4 cohorts, spanning early and late stages of psychotic illness. Early-stage cohorts included pat..

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University of Melbourne Researchers

Sidhant Chopra Author

Shona Francey Author

Brian O'Donoghue Author

Vanessa Cropley Author

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Grants

Awarded by NHMRC

Funding Acknowledgements

This study was supported by grant 1064704 from the Australian National Health and Medical Research Project; by grants from the NHMRC and Australian Research Council (Dr Francey, Aquino, Panteilis, Alvarez-Jimenez, and Fornito); by the Lundbeck Foundation (Dr Pantelis); by the Colonial Foundation, the National Alliance for Research on Schizophrenia and Depression, the Stanley Foundation, the NIH, Wellcome Trust, <EM><STRONG> </STRONG></EM>the Australian and Victorian governments, and Janssen-Cilag (Dr McGorry); by Senior Research Fellowship 1137687 from the NHMRC and a University of Melbourne Dame Kate Campbell Fellowship (Dr Nelson); and by the computational infrastructure provided by the MASSIVE HPC facility (www.massive.org.au). Janssen-Cilag partially supported the early years of the clinical trial data set included in this study with an unrestricted investigator-initiated grant and provided risperidone, paliperidone, and matched placebo for the first 30 participants.